EVŌQ Nano’s antimicrobial platform proves effective against HAIs

US-based nanoscience company EVŌQ Nano’s antimicrobial medical device platform has demonstrated effectiveness against the world’s leading pathogens implicated in healthcare-associated infections (HAIs).

Extensive lab tests, conducted in collaboration with leading catheter manufacturers, revealed that catheters embedded with EVŌQ Nano’s EVQ-218 nanoparticle demonstrated a strong antibacterial, antifungal, and antibiofilm efficacy, including a 7-8 log reduction

in Staphylococcus aureus, a 6-7.5 log reduction in Pseudomonas aeruginosa, and a 5-6.5 log reduction in Candida albicans – key pathogens in HAIs.

Often linked to indwelling devices such as catheters, notably catheter-associated urinary tract infections

“With its proven ability to resist microbial growth and biofilm formation without triggering antimicrobial resistance, this platform has the potential to significantly impact device-related infections — much like the antibiotic revolution transformed infectious disease treatment a century ago.”

Shaun Rothwell, EVŌQ Nano CEO

(CAUTIs), HAIs stand as a primary concern. By integrating EVŌQ Nano’s EVQ-218 throughout the polymer, medical devices gain intrinsic antimicrobial defence. The company is strategically focusing on the catheter market, which, according to a market model on GlobalData’s Medical Intelligence Center, will be worth $861.6m in the US in 2030 (urinary catheters market).

EVQ-218, a non-ionic silver nanoparticle, halts bacterial growth by capturing sulphur, which hampers

bacterial metabolism without harming cell structures or disrupting the cell wall. This prevents the onset

of bacterial mutations that lead to antimicrobial resistance. Silver has a history of curbing bacterial growth in wounds, commonly used amid rising antibiotic resistance. However, silver ions tend to convert to silver sulphide or silver chloride, diminishing antimicrobial effectiveness.

Earlier this year, Roche’s chairman of the board of directors Severin Schwan emphasised the

importance of tackling antimicrobial resistance at the World Economic Forum Annual Meeting in Davos, Switzerland, which took place between 15–19 January 2024. Schwan cited companies leaving the antimicrobial sector due to the perception that there is no sustainable business model, as one reason there is a lack of incentive in the area.

In the announcement accompanying the data, EVŌQ Nano CEO Shaun Rothwell said: “With its proven ability to resist microbial growth and biofilm formation without triggering antimicrobial resistance, this platform has the potential to significantly impact device-related infections — much like the antibiotic revolution transformed infectious disease treatment a century ago.”